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KMID : 0370019900040000074
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Chung-Ang Journal of Pharmacal Sciences
1990 Volume.4 No. 0 p.74 ~ p.78
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Susceptibility Pattern of Staphylococcus Aureus(SA)
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Abstract
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The importance of MIRSA in infections due to SA continues to increase while alternative agents are limited. To study the changing patterns of in vitro susceptibility of SA, a total of 200 SA strains (100 MRSA / 100 MSSA) over two time periods (1987 / 1989) were tested against 16∼25 antibiotics including 8 quinolones.
MICs were measured by microdilution method in BHI broth at 35^0 with 10^5 cfu / ml inoculum size. MRSAs revealed a high drug resistance pattern with resistance rate of 90% for clindamycin, gentamicin, and rifampin(94%) over the time periods. Ciprofloxacin showed the highest increase in resistance with 46% incidence in 1989 vs 0% in 1987. MSSAs remained susceptible to vancomycin(100%), minocyclin(98%), rifampin(98%), clindamycin(90%), gentamicin(90%), and ciprofloxacin(90%).
It is concluded that methicillin susceptibility is a useful marker for SAs in predicting drug sensitivity. Minocyclin and rifampin may be useful alternative agents where vancomycin is contraindicated.
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